Role of plasminogen activator and plasminogen activator inhibitor type-1 in luteolysis—a minireview |
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Authors: | Liu Yixun Chen Yijun Feng Qiang Hu Zhaoyun |
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Institution: | (1) State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China |
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Abstract: | This minireview summarized our recent studies on the role of plasminogen activator (PA) and inhibitor type-1 (PAI-1) in luteolysis.
We have demonstrated that (1) both tissue type and urokinase type plasminogen activators (tPA and uPA) and a plasminogen activator
inhibitor type-1 (PAI-1) were present in the corpus luteum of rat and rhesus monkey; (2) decrease in progesterone production
in corpus luteum was well correlated with a sharp increase in tPA (but not uPA) and PAI-1 secretion; (3) exogenous tPA decreased
luteal progesterone synthesis while monoclonal antibodies increased progesterone production; (4) interferony inhibited luteal progesterone synthesis and stimulated tPA production while LH plus prolactin increased progesterone production
and decreased tPA (hut not uPA) activity in cultured luteal cells; (5) increase in proteolysis in the corpus luteum was also
correlated with decrease in progesterone production in mouse. These data suggest that local degradation of extracellular matrix
controlled by plasminogen activator and inhibitor is involved in the processes of luteolysis. |
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Keywords: | tissue type plasminogen activator (tPA) plasminogen activator inhibitor type-1 (PAI-1) luteolysis |
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