海藻酸钠/壳聚糖缓释微球的制备及性能

利用海藻酸钠(SA)聚阴离子及壳聚糖(CS)聚阳离子电解质的性质,以顺铂(DDP)为模型药,采用乳化交联法制备海藻酸钠-DDP缓释微球,根据静电吸附原理合成SA/DDP/CS复合载药微球.研究微球对药物分子的包载能力及释药特性.结果显示,制备的微球圆整,载药微球表面致密且分散性好,微球粒径在11.0～58.8μm之间,采用原子吸收分光光度计对载药微球的载药率、药物包封率和药物体外释放性质进行了测试和分析,结果表明载药微球缓释效果明显,减少了药物的投放量和投放次数,降低了毒副作用.

Preparation and property of alginate/chitosan microspheres for controlled releasing

Alginate (SA) and Chitosan (CS) were anion and cation polyelectrolyte,respectively. Using cis-Diamminedichloroplatinum (DDP) as the model drug, microspheres loaded with DDPwere prepared by crosslinking-emulsion method.Electrostatic absorption technique was used to prepare DDPmicrospheres coated with CS.The drug loaded in SA/CS/DDP microspheres was observed by SEM,and the results indicated that these microspheres showed dense surface and excellent sphere-forming ability, and the sizes of microspheres are in the range of 11.0—58.8μm.In addition,the drug loading ratio and efficiency as well as drug releasing curves were also investigated in vitro,and the results showed that SA/DDP/CSmicrospheres displayed an excellent drug controlled releasing.