| 夹板外固定大鼠胫骨闭合性骨折模型的建立 |
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| 引用本文： | 王峰,罗婷婷,李宪起.夹板外固定大鼠胫骨闭合性骨折模型的建立[J].实验动物科学,2015,32(5):7-10. |
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| 作者姓名： | 王峰 罗婷婷 李宪起 |
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| 摘 要： | 摘要: 目的通过建立大鼠闭合型胫骨骨折模型，为探讨骨折生理愈合机制提供实验依据。方法对14 只8 周龄雄性SD 大鼠通过自行设计的大鼠骨折造模支架行胫骨中段闭合性骨折，自制外夹板复位固定，并分别于骨折后0，7， 14， 21， 28 d 拍摄X 线观察骨折类型以及骨折的愈合情况。结果X 线显示10 只为横行骨折，3只斜形骨折，1只为粉碎性骨折，并呈典型的二期愈合过程。结论自行设计的大鼠骨折造模支架及自制夹板外固定制作的大鼠闭合型胫骨骨折模型操作简便，减少了造模过程中人为的软硬组织损伤对骨折的影响，符合闭合性骨折模型的要求。
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| 关 键 词： | < p> 大鼠 闭合型骨折模型 夹板外固定< /p> |
Development of Splints Closed Fracture Model in Rats Tibia |
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| Abstract: | Abstract: Objective By establishing a standard rat model of closed tibial fracture，to explore the physiological fracture healing mechanisms to provide experimental basis． Method 14 male 8 weeks SD rats received midshaft tibial closed fracture induced by self-designed fracture model stent，and self-made splint for restoration and fixation，the fracture types and healing were observed by X-ray at 0，7， 14， 21， 28 days after surgery． Result X-ray shows13 for transverse or oblique fracture，1 for comminuted fracture，and is typical of the secondary healing process．Conclusion The closed tibial fracture model which induced by a self-designed fracture modeling stent and splints for external fixation can be obtained easily，avoiding or reducing the effects of hard or soft tissues damage on
fracture artificially，according with the requirement of standard closed fracture model． |
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| Keywords: | rat closed fracture model splint external fixation |
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