| 基于DNA/RNA的逻辑门与逻辑运算 |
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| 引用本文： | 俞洋,陆建华,王东方,裴昊,樊春海.基于DNA/RNA的逻辑门与逻辑运算[J].科学通报,2013,58(2):131-140. |
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| 作者姓名： | 俞洋 陆建华 王东方 裴昊 樊春海 |
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| 作者单位： | 上海科技管理干部学院电子信息系;中国科学院上海应用物理研究所物理生物学实验室 |
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| 摘 要： | DNA和RNA具有精确的分子识别能力以及强大的信号存储能力. 利用DNA/RNA分子的生物学特性来构建分子级别的逻辑门并实现逻辑运算是近年来计算机科学和分子生物学交叉产生的新兴领域, 引起了研究者的广泛关注. 本文介绍了利用DNA/RNA分子的酶活性、结构特性来构建逻辑门的方法, 探讨了将单一逻辑门整合成复杂的逻辑运算的途径. 并且对于DNA/RNA逻辑门在体外检测和体内诊疗等生物医学中的应用进行了介绍, 提出了未来的发展方向.
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| 关 键 词： | 逻辑门 DNA计算 分子识别 自组装 生物计算机 |
| 收稿时间： | 2012-10-22 |
DNA/RNA based logic gates and computing |
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| YU Yang,LU JianHua,WANG DongFang,PEI Hao,& FAN ChunHai.DNA/RNA based logic gates and computing[J].Chinese Science Bulletin,2013,58(2):131-140. |
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| Authors: | YU Yang LU JianHua WANG DongFang PEI Hao & FAN ChunHai |
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| Institution: | 1 Department of Electronics and Information Technology,Shanghai Institute of Science & Technology Management,Shanghai 201800,China;2 Laboratory of Physical Biology,Shanghai Institute of Applied Physics,Chinese Academy of Science,Shanghai 201800,China |
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| Abstract: | DNA and RNA molecules possess precise recognition and powerful signal storage abilities. By exploiting their biological properties, it is possible to construct molecule-scale logic gates and realize logistic operations which, as an emerging multidisciplinary area between computer sciences and molecular biology, has intrigued great research attention. In this article, we summarize methods to construct logic gates by exploiting enzymatic and structural properties of DNA and RNA, and approaches to integrate logic gates into complex logistic operations. Finally, we introduce biomedical applications of DNA/RNA logic gates for in-vitro detection and in-vivo diagnosis and therapy. |
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| Keywords: | logic gate DNA computing molecular recognition self-assemble bio-molecular computer |
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