| 肿瘤生物免疫治疗研究进展 |
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| 引用本文： | 吴艳红,王慧茹,邓振领,葛科立,张叔人.肿瘤生物免疫治疗研究进展[J].科技导报(北京),2014,32(26):27-36. |
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| 作者姓名： | 吴艳红 王慧茹 邓振领 葛科立 张叔人 |
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| 作者单位： | 中国医学科学院北京协和医学院肿瘤医院肿瘤研究所免疫室, 北京 100021 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)项目(2012CB917104) |
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| 摘 要： | 肿瘤免疫编辑理论的提出阐述了免疫系统在肿瘤发生发展中不可忽视的作用。靶向肿瘤免疫负调控的单克隆抗体在临床的成功应用，更确定了调控免疫系统对有效治疗肿瘤的重要性。未来大有发展潜力的联合免疫治疗手段主要有抗体、细胞因子、肿瘤疫苗、过继免疫细胞治疗和溶瘤病毒等。免疫治疗联合传统的肿瘤治疗包括手术、放疗和化疗，是今后提高肿瘤治疗效果的重要研究和应用方向。本文主要综述抗体治疗、肿瘤疫苗治疗、细胞过继免疫治疗、溶瘤病毒治疗的研究进展，提出相关研究中存在的问题，并对其进行展望。
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| 关 键 词： | 肿瘤免疫治疗 抗体 肿瘤疫苗 免疫细胞过继治疗 溶瘤病毒 |
| 收稿时间： | 2014-08-12 |
Progress in Cancer Bio-immunotherapy |
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| WU Yanhong,WANG Huiru,DENG Zhenling,GE Keli,ZHANG Shuren.Progress in Cancer Bio-immunotherapy[J].Science & Technology Review,2014,32(26):27-36. |
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| Authors: | WU Yanhong WANG Huiru DENG Zhenling GE Keli ZHANG Shuren |
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| Institution: | Department of Immunology, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China |
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| Abstract: | The cancer immunoediting theory dipicts the significance of immune system in cancer development and progression. The success of antibodies targeting the suppressive immune component has emphasized the importance and effectiveness of immunotherapy in cancer treatment. Combined with surgery, radiotherapy and chemotherapy, immunotherapy including antibody therapy, cytokine, cancer vaccine, adoptive immune cell transfer and oncolytic virus is a potential and promising treatment for cancer. This review will mainly introduce the progress in antibody therapy, cancer vaccine, adoptive cellular immunotherapy and oncolytic virus, as well as point out the problems and future development in cancer bio-immunotherapy. |
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| Keywords: | cancer immunotherapy antibody cancer vaccine adoptive immune cell transfer oncolytic virus |
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