tRNA structural and functional changes induced by oxidative stress |
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| Authors: | Barbara Nawrot Elzbieta Sochacka Markus Düchler |
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| Institution: | (1) Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112, Sienkiewicza Street, 90-363 Lodz, Poland;(2) Institute of Organic Chemistry, Technical University of Lodz, Zeromskiego 116, 90-924 Lodz, Poland; |
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| Abstract: | Oxidatively damaged biomolecules impair cellular functions and contribute to the pathology of a variety of diseases. RNA is
also attacked by reactive oxygen species, and oxidized RNA is increasingly recognized as an important contributor to neurodegenerative
complications in humans. Recently, evidence has accumulated supporting the notion that tRNA is involved in cellular responses
to various stress conditions. This review focuses on the intriguing consequences of oxidative modification of tRNA at the
structural and functional level. |
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