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Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes |
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| Authors: | M B Castillo M D Gonzalez G Burton C P Lantos A Roldán |
| Abstract: | A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11 beta-ol-3,20-dione and pregna-1,4-diene-11 beta-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions. |
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