| 几种抗肿瘤药物对ODC的抑制作用 |
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| 引用本文： | 陈盛 陆永智. 几种抗肿瘤药物对ODC的抑制作用[J]. 福建师范大学学报(自然科学版), 1989, 5(1): 59-64 |
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| 作者姓名： | 陈盛 陆永智 |
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| 作者单位： | 福建师范大学高分子研究所,福建师范大学生物系 |
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| 摘 要： | 本文报道用酸滴定法定量测定鼠伤寒沙门氏菌鸟氨酸脱羧酶活性的方法。测定了丝裂霉素、“776”香菇多糖、博来霉素、米托葸醌、顺氨氯铂、安瘤乳口服液、环磷酰胺等抗肿瘤药物对鸟氨酸脱羧酶活性的抑制作用。此外,还测定了丝裂霉素,“776”香菇多糖、博来霉素三种抗肿瘤药物对鸟氨酸脱羧酶活性抑制作用的动力学类型。
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| 关 键 词： | 抗肿瘤药物 抑制作用 乌氨酸脱羧酶 |
The Inhibition of Some Anti-tumour Drugs to ODC |
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| Chen Sheng Lu Yongzhi. The Inhibition of Some Anti-tumour Drugs to ODC[J]. Journal of Fujian Teachers University(Natural Science), 1989, 5(1): 59-64 |
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| Authors: | Chen Sheng Lu Yongzhi |
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| Affiliation: | Chen Sheng Lu Yongzhi (Institute of Polymer Science) (Department of Biology) |
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| Abstract: | By the method of acid titration assay for ornithine decarboxylase activity induced by substrate in salmonella typhimurium, the inhibition of some anti-tumour drugs(mitomycin c, "776" lentinan, bleomycin, mitoxautrone, et at. )to ODe is reported in this paper. The inhibition kinetics of three anti-tumour drugs to ODC have also been examined. The results indicate that mitomycin c and bleomycin are the irreversible inhibitors of ODC, and "776" lentinan is reversible inhibitor. |
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| Keywords: | salmonella typhimurium, ornithine decarboxylasc,assay of activity, mitomycin, " 776" lentinan, bleomycin,inhibition, |
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