Tumor suppressor role of protein 4.1B/DAL-1 |
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Authors: | Zi Wang Ji Zhang Mao Ye Min Zhu Bin Zhang Mridul Roy Jing Liu Xiuli An |
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Institution: | 1. Molecular Biology Research Center, School of Life Sciences, Central South University, 110 Xiangya Road, Changsha, 410078, China 2. Department of Hematology, The First Affiliated Hospital, University of South China, Hengyang, 421001, China 3. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, 410082, China 4. Department of Histology and Embryology, Xiangya School Medicine, Central South University, Changsha, 410083, China 5. State Key Laboratory of Medical Genetics, Central South University, 110 Xiangya Road, Changsha, 410078, China 6. Laboratory of Membrane Biology, New York Blood Center, 310 E 67th Street, New York, 10065, USA
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Abstract: | Protein 4.1B/DAL-1 is a membrane skeletal protein that belongs to the protein 4.1 family. Protein 4.1B/DAL-1 is localized to sites of cell–cell contact and functions as an adapter protein, linking the plasma membrane to the cytoskeleton or associated cytoplasmic signaling effectors and facilitating their activities in various pathways. Protein 4.1B/DAL-1 is involved in various cytoskeleton-associated processes, such as cell motility and adhesion. Moreover, protein 4.1B/DAL-1 also plays a regulatory role in cell growth, differentiation, and the establishment of epithelial-like cell structures. Protein 4.1B/DAL-1 is normally expressed in multiple human tissues, but loss of its expression or prominent down-regulation of its expression is frequently observed in corresponding tumor tissues and tumor cell lines, suggesting that protein 4.1B/DAL-1 is involved in the molecular pathogenesis of these tumors and acts as a potential tumor suppressor. This review will focus on the structure of protein 4.1B/DAL-1, 4.1B/DAL-1-interacting molecules, 4.1B/DAL-1 inactivation and tumor progression, and anti-tumor activity of the 4.1B/DAL-1. |
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