铜绿假单胞菌注射液对H22小鼠移植瘤的辅助治疗效果 |
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引用本文: | 饶子亮,郑佳琳,黄 威,王 弋,潘诗云,黄绮玲,邝少松. 铜绿假单胞菌注射液对H22小鼠移植瘤的辅助治疗效果[J]. 实验动物科学, 2018, 35(4): 40 |
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作者姓名: | 饶子亮 郑佳琳 黄 威 王 弋 潘诗云 黄绮玲 邝少松 |
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摘 要: | 目的 研究铜绿假单胞菌注射液联合化疗对H22小鼠移植瘤的影响。方法 采用H22细胞株,移植53只BALB/c小鼠皮下。取肿块大小相对均匀的48只小鼠随机分成6组:空白对照、铜绿假单胞菌组、联合顺铂组、联合阿霉素组、顺铂组、阿霉素组,8只/组。连续给药14 d。结果 联合顺铂组、顺铂组的抑瘤率为49.2%、46.6%,联合阿霉素组、阿霉素组的抑瘤率为32.1%、19.8%。结论 铜绿假单胞菌注射液对H22小鼠移植瘤的阿霉素化疗有一定的增强效果。
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关 键 词: | 铜绿假单胞菌注射液 联合化疗 H22 |
The Efficacy of Pseudomonas Aeruginosa-mannose Sensitive Hemagglutinin on H22 Mice Transplanted Tumor |
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Abstract: | Objective The efficacy of pseudomonas aeruginosa-mannose sensitive hemagglutinin on H22 mice transplanted tumor.Method H22 cells were implanted into the subcutaneously of 53 BALB/c mice. Forty eight mice were randomly divided into 6 groups. And set up Control group, Pseudomonas aeruginosa group, Combined cisplatin group, Combined adriamycin group, cisplatin group, adriamycin group, 8 mice/group. Continuous administration for 14 days. Result The tumor inhibition rate of combined cisplatin group and cisplatin group were 49.2% and 46.6%, and the tumor inhibition rate of adriamycin group and adriamycin group was about 32.1% and 19.8%.Conclusion Pseudomonas Aeruginosa Injection can enhance the effect of adriamycin chemotherapy on H22 mice. |
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Keywords: | Pseudomonas aeruginosa-mannose sensitive hemagglutinin combined chemotherapy H22 |
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