铜绿假单胞菌注射液对H22小鼠移植瘤的辅助治疗效果

目的 研究铜绿假单胞菌注射液联合化疗对H22小鼠移植瘤的影响。方法 采用H22细胞株，移植53只BALB/c小鼠皮下。取肿块大小相对均匀的48只小鼠随机分成6组：空白对照、铜绿假单胞菌组、联合顺铂组、联合阿霉素组、顺铂组、阿霉素组，8只/组。连续给药14 d。结果 联合顺铂组、顺铂组的抑瘤率为49.2%、46.6%，联合阿霉素组、阿霉素组的抑瘤率为32.1%、19.8%。结论 铜绿假单胞菌注射液对H22小鼠移植瘤的阿霉素化疗有一定的增强效果。

The Efficacy of Pseudomonas Aeruginosa-mannose Sensitive Hemagglutinin on H22 Mice Transplanted Tumor

Objective The efficacy of pseudomonas aeruginosa-mannose sensitive hemagglutinin on H22 mice transplanted tumor．Method H22 cells were implanted into the subcutaneously of 53 BALB/c mice. Forty eight mice were randomly divided into 6 groups. And set up Control group, Pseudomonas aeruginosa group, Combined cisplatin group, Combined adriamycin group, cisplatin group, adriamycin group, 8 mice/group. Continuous administration for 14 days. Result The tumor inhibition rate of combined cisplatin group and cisplatin group were 49.2% and 46.6%, and the tumor inhibition rate of adriamycin group and adriamycin group was about 32.1% and 19.8%．Conclusion Pseudomonas Aeruginosa Injection can enhance the effect of adriamycin chemotherapy on H22 mice．