Mapping and characterization of two relevance networks from SNP and gene levels |
| |
Authors: | Wei Jiang Lijie Zhang Bo Na Lihong Wang Jiankai Xu Xia Li Yadong Wang Shaoqi Rao |
| |
Institution: | 1. College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province,Harbin Medical University,Harbin 150081,China 2. Department of Mathematics and Computer Science,Harbin Institute of Technology,Harbin 150080,China 3. College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province,Harbin Medical University,Harbin 150081,China;Department of Mathematics and Computer Science,Harbin Institute of Technology,Harbin 150080,China;Department of Bioinformatics,Capital University of Medical Sciences,Beijing 100084,China;4 Department of Cardiovascular Medicine and Molecular Cardiology,The Cleveland Clinic Foundation,9600 Euclid Avenue,Cleveland,OH 44195,USA |
| |
Abstract: | Variations of gene expression and DNA sequence are genetically associated.The goal of this study was to build genetic networks to map from SNPs to gene expressions and to characterize the two different kinds of networks.We employed mutual information to evaluate the strength of SNP-SNP and gene-gene associations based on SNPs identity by descent (IBD) data and differences of gene expressions.We applied the approach to one dataset of Genetics of Gene Expression in Humans,and discovered that both the SNP relevance network and the gene relevance network approximated the scale-free topology.We also found that 12.09% of SNP-SNP interactions matched 24.49% of gene-gene interactions,which was consistent with that of the previous studies.Finally,we identified 49 hub SNPs and 115 hub genes in their relevance networks,in which 27 hub SNPs were associated with 25 hub genes.(C) 2009 National Natural Science Foundation of China and Chinese Academy of Sciences.Published by Elsevier Limited and Science in China Press.All rights reserved. |
| |
Keywords: | SNP relevance network Gene relevance network Network mapping Network topology |
本文献已被 维普 万方数据 ScienceDirect 等数据库收录! |
| 点击此处可从《自然科学进展(英文版)》浏览原始摘要信息 |
| 点击此处可从《自然科学进展(英文版)》下载免费的PDF全文 |
|