| 小鼠白细胞减少症模型的建立 |
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| 引用本文： | 田枫,张阔,康爱君,周淑佩,郑振辉. 小鼠白细胞减少症模型的建立[J]. 实验动物科学, 2008, 25(2): 1-3 |
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| 作者姓名： | 田枫 张阔 康爱君 周淑佩 郑振辉 |
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| 作者单位： | 北京大学医学部实验动物科学部,海淀,100083 |
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| 摘 要： | 目的为小鼠白细胞减少症模型的建立提供基础资料。方法选用ICR小鼠和C57BL/6J小鼠以5Gy的剂量60Co-γ射线一次性全身照射小鼠,测定小鼠外周血白细胞总数。结果在本实验条件下,ICR小鼠的正常白细胞数量极显著低于C57BL/6J小鼠;雄性C57BL/6J在照射后第3 d白细胞数量显著高于其雌性小鼠。结论小鼠的品系、性别对60Co-γ射线照射建立的白细胞减少症模型具有一定的影响。
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| 关 键 词： | 小鼠 白细胞减少症 辐射 |
| 文章编号： | 1006-6179(2008)02-0001-03 |
| 收稿时间： | 2008-04-28 |
| 修稿时间： | 2007-06-11 |
Radiation-induced Mice Leucopenia Dependent on Strain and Sex |
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| TIAN Feng,ZHANG Kuo,KANG Ai-jun,ZHOU Shu-pei,ZHENG Zhen-hui. Radiation-induced Mice Leucopenia Dependent on Strain and Sex[J]. Laboratory Animal Science, 2008, 25(2): 1-3 |
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| Authors: | TIAN Feng ZHANG Kuo KANG Ai-jun ZHOU Shu-pei ZHENG Zhen-hui |
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| Affiliation: | TIAN Feng,ZHANG Kuo,KANG Ai-jun,ZHOU Shu-pei,ZHENG Zhen-hui(Department of Laboratory Animal Science,Health Science Center,P.K.U.,Beijing 100083) |
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| Abstract: | Objective To develop a mice leucopenia model induced by()~(60)Co gamma-ray.Methods ICR and C57BL/6J mice were subjected to single systemic()~(60)Co gamma-ray radiation a dose of 50 Gy,and peripheral white blood cell(WBC) count was taken for both radiated and non-radiated mice.Results Significantly elevated WBC count after radiation was observed in both strains.The WBC count in normal ICR mice was very significantly lower than that in C57BL/6J mice,and the WBC count in male C57BL/6J mice three days post rad... |
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| Keywords: | Mice Leucopenia Radiation |
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