| 蒽环类碱性药物在亲水作用色谱中保留机理的研究 |
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| 引用本文： | 李瑞萍.蒽环类碱性药物在亲水作用色谱中保留机理的研究[J].三峡大学学报(自然科学版),2007,29(3):265-268. |
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| 作者姓名： | 李瑞萍 |
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| 作者单位： | 三峡大学Alan G. MacDiarmid再生能源研究所,湖北,宜昌,443002 |
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| 基金项目： | 湖北省教育厅自然科学基金;三峡大学校科研和教改项目 |
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| 摘 要： | 采用以高纯硅胶为色谱柱,水-有机溶剂为流动相的亲水作用色谱模式,通过改变流动相中有机溶剂类型及浓度、酸类型、缓冲液pH值及离子强度,探讨了蒽环类碱性药物在该色谱模式下的保留机理.结果表明,在所考察条件下,溶质的保留机理主要为吸附及离子交换混合保留机理.
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| 关 键 词： | 亲水作用色谱 高纯硅胶 蒽环类碱性药物 保留机理 |
| 文章编号： | 1672-948X（2007）03-0265-04 |
| 修稿时间： | 2006-12-10 |
Retention Mechanism of Anthracycline Basic Drugs in Hydrophilic Interaction Chromatography |
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| Li Ruiping.Retention Mechanism of Anthracycline Basic Drugs in Hydrophilic Interaction Chromatography[J].Journal of China Three Gorges University(Natural Sciences),2007,29(3):265-268. |
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| Authors: | Li Ruiping |
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| Institution: | Alan G. MacDiarmid Research Institute of Renewable Energy, China Three Gorges Univ. , Yichang 443002, China |
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| Abstract: | Hydrophilic interaction chromatography(HILIC) has been applied for the separation of anthracycline basic drugs using high purity silica column with an aqueous-organic mobile phase.The retention mechanism of this kind of basic compounds has been discussed by changing the parameters such as organic modifier,acid type,buffer pH and ionic strength.Results indicate that the retention mechanism is a mixed-mode of adsorption and ion exchange under the investigated conditions. |
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| Keywords: | hydrophilic interaction chromatography high purity silica anthracycline basic drugs retention mechanism |
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