| 中药柴胡提取物对人肝癌细胞BEL-7402细胞内VCR蓄积的影响 |
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| 引用本文： | 朱建强,韩晓红,薛延军. 中药柴胡提取物对人肝癌细胞BEL-7402细胞内VCR蓄积的影响[J]. 北华大学学报(自然科学版), 2005, 6(1): 62-64 |
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| 作者姓名： | 朱建强 韩晓红 薛延军 |
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| 作者单位： | 北华大学医学院 吉林吉林 132013(朱建强，韩晓红)，吉林医药学院 吉林吉林 132033(薛延军) |
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| 基金项目： | 吉林省教育厅科研基金项目(吉教合字2000第26号) |
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| 摘 要： | 目的 测定中药柴胡(BupleurunChineseDC,BCDC)提取物对人肝癌细胞BEL 7402细胞内VCR蓄积的影响,以探索柴胡逆转BEL 7402细胞多药耐药的机制.方法 高效液相色谱法测定BCDC作用于BEL 7402后细胞内VCR蓄积情况的变化.结果 柴胡可使人肝癌细胞BEL 7402细胞内VCR浓度升高(P<0.01).结论 柴胡可以增加VCR在BEL 7402细胞内的积聚浓度,部分逆转BEL 7402细胞的MDR.
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| 关 键 词： | 柴胡 长春新碱 BEL-7402细胞 高效液相色谱法 |
| 文章编号： | 1009-4822(2005)01-0062-03 |
| 修稿时间： | 2004-09-26 |
Effects of the Extracts from BCDC on Cellular VCR Concentration of Human Hepatoma BEL-7402 Cells |
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| ZHU Jian-qiang,HAN Xiao-hong,XUE Yan-jun. Effects of the Extracts from BCDC on Cellular VCR Concentration of Human Hepatoma BEL-7402 Cells[J]. Journal of Beihua University(Natural Science), 2005, 6(1): 62-64 |
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| Authors: | ZHU Jian-qiang HAN Xiao-hong XUE Yan-jun |
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| Affiliation: | ZHU Jian-qiang~1,HAN Xiao-hong~1,XUE Yan-jun~2 |
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| Abstract: | ObjectiveTo measure the effects of the extracts from BCDC on cellular VCR concentration of human hepatoma BEL-7402 cells, in order to explore the mechanism of BCDC reversing the multidrug resistance of BEL-7402 cells of human hepatoma.MethodsCellular VCR concentration was examined by high performance liquid chromatography(HPLC).ResultsThe BCDC can increase cellular VCR concentration of BEL-7402 cell.ConclusionBCDC could increase intracellular VCR concentration of BEL-7402 cell line. |
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| Keywords: | Bupleurun Chinese DC Vincristine BEL-7402 cells High performance liquid chromatography |
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