| 纳米金在DNA电化学传感器中的应用研究 |
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| 引用本文： | 王垄,张纪梅,代昭,许世超. 纳米金在DNA电化学传感器中的应用研究[J]. 实验室科学, 2010, 13(6): 96-98. DOI: 10.3969/j.issn.1672-4305.2010.06.032 |
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| 作者姓名： | 王垄 张纪梅 代昭 许世超 |
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| 作者单位： | 天津工业大学环境与化学工程学院,天津300160 |
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| 摘 要： | 利用自组装单分子膜原理,通过层层组装的方法将金纳米粒子(AuNPs)和DNA探针分别固定到金电极表面制备成探针电极。结果表明纳米金可以使响应电流大大增强,有利于提高检测的灵敏度;同时DNA自组装到纳米金修饰的金电极上,形成一层致密的分子膜,可使响应电流下降。
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| 关 键 词： | DNA电化学传感器 纳米金 自组装 杂交 |
Applications of gold nanoparticals in DNA electrochemical sensor |
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| WANG Long,ZHANG Ji-mei,DAI Zhao,XU Shi-chao. Applications of gold nanoparticals in DNA electrochemical sensor[J]. Laboratory Science, 2010, 13(6): 96-98. DOI: 10.3969/j.issn.1672-4305.2010.06.032 |
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| Authors: | WANG Long ZHANG Ji-mei DAI Zhao XU Shi-chao |
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| Affiliation: | (School of Environmental and Chemical Engineering,Tianjin Polytechnic University,Tianjin 300160,China) |
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| Abstract: | According to the principle of self-assembled monalayers,Au nano particles（AuNPs） and the end thoil-modified DNA are self-assembled onto the surface of Au electrode to form a sensing probe based on layer-by-layer method.The result shows that the response current and detection sensitivity are improved by assembled Au nano particles.While the current is declined because of a compact monolayer formed by DNA self-assembling onto the Au electrode with gold nanoparticles. |
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| Keywords: | DNA electrochemical biosensor gold nanoparticles self-assembled hybridization |
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