Inhibition of steroidΔ
4 reductase by heparin: Studies with desoxycorticosterone,progesterone, androstenedione and testosterone |
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| Authors: | Patricia T Krzanowski R C Troop |
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| Institution: | (1) Division of Clinical Pharmacology, University of Tennessee, Medical Units, 38103 Memphis, Tennessee, USA |
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| Abstract: | Zusammenfassung Heparin hemmt die Reduktion der Doppelbindung in 4-Stellung des Rings A einer Reihe von C-11-desoxy,
4-4-keto-Steroiden in der Rattenleber. Es scheint, dass Heparin mit NADPH um das Steroid-reduktase-Apoenzym konkurriert.
This work was supported by grant No. AM-09151 from The National Institutes of Health, U.S.P.H.S. |
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