Dual role of cAMP duringDictyostelium development |
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| Authors: | C. D. Reymond P. Schaap M. Véron J. G. Williams |
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| Affiliation: | (1) Institut d'Histologie et d'Embryologie, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, (Switzerland);(2) Clusius Laboratory, Institute of Molecular Plant Sciences, Leiden University, Wassenaarseweg 64, NL-2333 AL Leiden, (The Netherlands);(3) Unité de Biochimie Cellulaire, Institut Pasteur, 28 Rue du Dr. Roux, F-75724 Paris, Cedex 15, (France);(4) MRC Laboratory for Cell Biology, University College London, Gower Street, WC1E 6BT London, UK |
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| Abstract: | cAMP plays an essential role duringDictyostelium development both outside and inside the cell. Membrane-bound receptors and adenylyl cyclase are responsible for sensing and producing extracellular cAMP, whereas a phosphodiesterase is responsible for maintaining a low basal level. The molecular events underlying this type of hormone like signalling, which are now beginning to be deciphered, will be presented, in the light of cAMP analogue studies. The importance of intracellular cAMP for cell differentiation has been demonstrated by the central role of the cAMP dependent protein kinase. Mutants as well as strains obtained by reverse genetics will be reviewed which lead to our current understanding of the role of intracellular cAMP in the differentiation of both stalk and spore cells. |
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| Keywords: | Cyclic AMP receptors adenylyl cyclase phosphodiesterase protein kinase cAMP analogs |
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