| 1—取代氮杂环庚烷—2—酮的合成 |
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| 引用本文： | 周瑞仪,张洪奎.1—取代氮杂环庚烷—2—酮的合成[J].厦门大学学报(自然科学版),1990,29(5):596-598. |
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| 作者姓名： | 周瑞仪 张洪奎 |
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| 作者单位： | 厦门大学化学系
(周瑞仪，张洪奎)，厦门大学化学系(任海英) |
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| 摘 要： | 1—取代氮杂环庚烷-2-酮类有比较重要的生理活性,如1-十二烷基氮杂环庚烷-2-酮为目前受重视的新型高效、无毒的透皮吸收促进剂。但内酰胺氮上氢原子的酸性很弱,较难发生N-烷基化反应,为提高1-取代内酰胺的合成产率,我们用混合无机碱KOH/K_2CO_3为缚酸剂,聚
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| 关 键 词： | 氮杂环庚烷酮 合成 N－烷基化 |
Studies on Synthesis of l-substituted Azacycloheptan-2-ones |
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| Zhou Ruiyi Zhang Hongkui Ren Haiying Dept. of Chem..Studies on Synthesis of l-substituted Azacycloheptan-2-ones[J].Journal of Xiamen University(Natural Science),1990,29(5):596-598. |
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| Authors: | Zhou Ruiyi Zhang Hongkui Ren Haiying Dept of Chem |
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| Institution: | Zhou Ruiyi Zhang Hongkui Ren Haiying Dept. of Chem. |
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| Abstract: | 1-substituted azacycloheptan-2-ones were synthesized by means of solid-liquid phase transfer catalysis of polyethylene glycol. In this PTC-alkylation we have found that a mixture of solid NaOH and K2C03as a base is more suitable for N-alkrlation of caprolactam. The procedure is simple to op eiate and inexpensive |
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| Keywords: | 1-substituted azacycloheptan-2-ones Phase transfer catalysis (PTC) Polyethylene glycoi N-alkylation Caprolactam |
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