Variations in cardiac noradrenaline content during sodium loading in hypertension prone and resistant rats |
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| Authors: | K. H. Le Quan-Bui Marie-Aude Devynck Marie-Gabrielle Pernollet D. Ben-Ishay P. Meyer |
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| Affiliation: | (1) INSERM U7 Research Unit, Department of Nephrology, Hôpital Necker, 161 rue de Sèvres, F-75015 Paris, (France);(2) Hadassah Medica School, Jerusalem, (Israel) |
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| Abstract: | Summary The cardiac catecholamine content of Sabra rats and their 2 genetically derived substrains, hypertension prone and resistant rats, was studied by high pressure liquid chromatography and electrochemical detection. Both in the control period and after sodium and DOCA administration the cardiac noradrenaline level is higher in hypertension resistant rats than in Sabra rats, and also higher than in hypertension prone rats. This finding suggests that a reduction of the cardiac sympathetic nervous tone is involved in the genetic resistance to sodium. |
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