Endothelial injury by nicotine and its prevention

Summary Nicotine administered i.v. or p.o. in doses above 0.0125 mg/kg to the rat caused a highly significant increase in circulating anuclear carcasses of endothelial cells estimated by an original method. This effect of nicotine was completely prevented by a prior oral administration of the flavonoids hydroxyethylrutosides (HR) or Mono-7-HR.Acknowledgment. Both flavonoid preparations were kindly supplied by Zyma SA, Nyon Switzerland.