Cytokinesis in development and disease: variations on a common theme |
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Authors: | R Li |
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Institution: | (1) Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA |
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Abstract: | Cytokinesis is a crucial step in cell proliferation, and remarkably, it is also an important mechanism for developmental regulation
in the generation of diverse cell types in eukaryotic organisms. Successful cytokinesis relies on the assembly and activation
of an actomyosin-based contractile ring and membrane deposition/fusion in a spatially and temporally precise manner. As such,
the molecular pathways governing cytokinesis are highly complex, involving a large number of components forming intricate
interactive networks. The complexity of this system, however, may have also provided a rich platform for evolutionary ‘tinkering’
to achieve specific morphogenetic and developmental outcomes. Furthermore, failed or altered cytokinesis appears to contribute
to the development of cancer in unexpected ways.
Received 25 June 2007; received after revision 20 July 2007; accepted 16 August 2007 |
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Keywords: | Cytokinesis asymmetric cell division polar body extrusion enucleation polyploidization |
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