Molecular cloning and characterization of the rat NMDA receptor. |
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| Authors: | K Moriyoshi M Masu T Ishii R Shigemoto N Mizuno S Nakanishi |
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| Affiliation: | Institute for Immunology, Kyoto University Faculty of Medicine, Japan. |
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| Abstract: | A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum. |
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