| 基于sub-tile的对称有界DNA结构自组装及应用 |
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| 引用本文： | 黄春,吴艳敏,姚莉娜,张勋才,王延峰,崔光照.基于sub-tile的对称有界DNA结构自组装及应用[J].郑州大学学报(自然科学版),2014(3):102-106. |
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| 作者姓名： | 黄春 吴艳敏 姚莉娜 张勋才 王延峰 崔光照 |
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| 作者单位： | 郑州轻工业学院电气信息工程学院,河南郑州450002 |
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| 基金项目： | 基金项目：国家自然科学基金资助项目,编号61070238,61272022,U1304620;河南省基础与前沿技术研究计划项目,编号122300413211,132300410183;河南省创新型科技人才队伍建设工程支持项目,编号124200510017;郑州市科技人才队伍建设计划（科技领军人才）项目,编号131P13RC648;河南省教育厅科学技术研究重点项目,编号13A413371. |
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| 摘 要： | 使用一种基于DNA sub-tile的自组装策略,通过模块化的方式灵活构建多种刚性DNA tile,同时利用DNA tile 的对称性,创建多种有限尺寸,空间可寻址的纳米网格结构,并阐述其可能在癌症治疗中作为小分子纳米药物颗粒运载工具,实现定向给药的潜在应用.
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| 关 键 词： | DNA tile自组装 有限尺寸 可寻址 药物运载 |
DNA Self-assembly and Application on Symmetric and Bounded DNA Structure Based on Sub-tile |
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| HUANG Chun,WU Yan-min,YAO Li-na,ZHANG Xun-cai,WANG Yan-feng,CUI Guang-zhao.DNA Self-assembly and Application on Symmetric and Bounded DNA Structure Based on Sub-tile[J].Journal of Zhengzhou University (Natural Science),2014(3):102-106. |
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| Authors: | HUANG Chun WU Yan-min YAO Li-na ZHANG Xun-cai WANG Yan-feng CUI Guang-zhao |
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| Institution: | (Electricity and Information Engineering School, Zhengzhou University of Light Industry, Zhengzhou 450002, China) |
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| Abstract: | DNA self-assemble strategy based on a special DNA sub-tile was used, and a variety of rigid DNA tiles was created by the modular way. At the same time, a variety of limited and addressable nanomesh structure was created with the symmetry of DNA tiles. The small molecular nano particles could be used as drug carriers in the treatment of cancer, and the potential application of directional drug delivery might be possible |
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| Keywords: | sub-tile DNA self-assembly finite size addressable drug delivery |
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