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Effect of propane sultone pretreatment on Friend virus leukemogenesis in mice |
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| Authors: | R B Raikow J P OKunewick M J Buffo D L Kociban |
| Institution: | (1) Allegheny-Singer Research Institute, 320 East North Avenue, 15212 Pittsburgh, Pennsylvania, USA |
| Abstract: | Summary Propane sultone (PS) injected i.p. 24 or more hours before Friend leukemia virus increased the incidence of lymphoma in SJL/J mice and at a higher dose increased the incidence of erythroleukemia in B10SJF1 mice. PS at the same time also decreased hematopoietic stem cell clonogenicity. |
| Keywords: | Mouse erythroleukemia propane sultane Friend leukemia virus carcinogenesis clonogenicity |
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