一种周围血管内放射治疗计划的优化方法

为了促进内放射治疗技术尽早运用到PTA术后周围血管再狭窄的治疗中去,提出一种基于主动漫游的周围血管内放射治疗计划的混合优化方法.首先利用主动漫游获取血管的几何结构,然后建立数学模型对治疗计划方案进行优化.为了加快优化速度,根据待优化参数的属性,综合运用BFGS算法和模拟退火算法来进行优化.实验结果表明, 采用上述方法得到了较好的剂量表面直方图,等处方剂量线与治疗区血管内表面吻合良好,并具有较快的计算速度.

Optimization of intravascular brachytherapy treatment planning in peripheral arteries

In order to promote the technology of intravascular brachytherapy to be applied timely in the restenosis treatment of peripheral arteries after percutaneous transluminal angioplasty(PTA), a method combining the active navigation with optimization algorithm for the planning of peripheral intravascular brachytherapy is proposed. According to the characteristics of the vessel obtained by active navigation, a method combining the broyden-fletcher-goldfarb-shanno (BFGS) with simulated annealing algorithm is applied to optimize the number of seeds, and the parameters associated with each seed such as the position, and the dwell time. Application of the method to a phantom model and animal models of stenosis shows that qualified dose surface histogram(DSH) could be obtained within a few minutes, the iso-prescribe-dose line fits well to the inner surface of vascular within treatment region.