| 正交设计优化N-乙酰-L-亮氨酸的合成研究 |
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| 引用本文： | 史黎黎,秦凡.正交设计优化N-乙酰-L-亮氨酸的合成研究[J].江汉大学学报(自然科学版),2007,35(2):44-46. |
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| 作者姓名： | 史黎黎 秦凡 |
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| 作者单位： | 1. 武汉大学,药学院,武汉,430072;江汉大学,文理学院,武汉,430056
2. 江汉大学,文理学院,武汉,430056 |
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| 摘 要： | 采用正交设计法,选择L9(34)表,研究N-乙酰-L-亮氨酸的合成,提高反应得率.实验发现,L-亮氨酸与乙酸酐的摩尔比为1∶1.2,乙酰化试剂分次加入,反应pH值为8～10,反应温度在10～15℃之间,酸化结晶pH值为1～3,反应时间1～2 h为适宜反应条件,产品得率可达到89%.
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| 关 键 词： | 正交设计 N-乙酰-L-亮氨酸 乙酰化 |
| 文章编号： | 1673-0143（2007）02-0044-03 |
| 修稿时间： | 2007-01-18 |
Study on Synthesis of N-acetyl-L-leueine by Orthogonal Design Method |
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| SHI Li-li,QIN Fan.Study on Synthesis of N-acetyl-L-leueine by Orthogonal Design Method[J].Journal of Jianghan University:Natural Sciences,2007,35(2):44-46. |
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| Authors: | SHI Li-li QIN Fan |
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| Institution: | 1. College of Pharmacy, Wuhan University, Wuhan430072, China; 2. School of Science and Arts, Jianghan University, Wuhan 430056, China |
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| Abstract: | Using orthogonal design method,adopting L9 34 table,to research the synthesis of N-acetyl-L-leucine,for improving the productive rate.The experiment shows the reasonable reaction condition is: molar ratio of L-leucine and acetic anhydride is 1∶1.2,the acetylation reagent is added graded,the pH of the solution is 8~10,the temperature of the reaction is 10~15℃,the pH of acidi-fication and crystallization is 1~3,the reaction time is 1~2 hours.Under the condition,the yiele can reach 89%. |
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| Keywords: | orthogonal design method N-acetyl-L-leucine acetylation |
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