| Alkylation of Chitosan as Nerve Conduit Biomaterial |
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| 作者姓名： | 邓劲光 公衍道 程明愚 赵南明 张秀芳 |
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| 作者单位： | DENG Jinguang，GONG Yandao，CHENG Mingyu ZHAO Nanming，ZHANG Xiufang State Key Laboratory of Biomembrane and Membrane Biotechnology，Department of Biological Sciences and Biotechnology，Tsinghua University，Beijing 100084，China |
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| 基金项目： | Supported by the National High-Tech Development Program of China (No. 2 0 0 1AA62 5 0 60 ) |
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| 摘 要： | IntroductionTrauma of the nervous system,which is one of themostimportant systems in the human body,oftenresults in permanent loss of function and greatdiscomfort for the patients.Study of peripheralnerve regeneration has not only relieved patientpain,but also provided insight into themechanisms of nerve development andregeneration. So both clinical medicine andfoundational life science benefit from the study ofperipheral nerve regeneration. There has been a resurgence of interest in thedevel…
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Alkylation of Chitosan as Nerve Conduit Biomaterial |
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| DENG Jinguang,GONG Yandao,CHENG Mingyu ZHAO Nanming,ZHANG Xiufang State Key Laboratory of Biomembrane and Membrane Biotechnology.Alkylation of Chitosan as Nerve Conduit Biomaterial[J].Tsinghua Science and Technology,2002,7(4). |
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| Authors: | DENG Jinguang GONG Yandao CHENG Mingyu ZHAO Nanming ZHANG Xiufang State Key Laboratory of Biomembrane and Membrane Biotechnology |
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| Institution: | DENG Jinguang,GONG Yandao,CHENG Mingyu ZHAO Nanming,ZHANG Xiufang State Key Laboratory of Biomembrane and Membrane Biotechnology,Department of Biological Sciences and Biotechnology,Tsinghua University,Beijing 100084,China |
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| Abstract: | Chitosan under physiological conditions is a degradable and biocompatible biomaterial with a wide variety of useful physicochemical properties. However, as a nerve conduit biomaterial, its solubility was very low, so chitosan was modified chemically to enhance its solubility. The free amino groups of long molecular chains in chitosan are responsible for its solubility, and the solubility could be adjusted by controlling the free amidogen capacity with N alkylation. The results show that the solubility of N alkylation chitosan is increased to 10%, which is an increase of 500%. |
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| Keywords: | chitosan nerve conduit alkylation solubility |
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