Genome sequence of the Brown Norway rat yields insights into mammalian evolution |
| |
Authors: | Gibbs Richard A Weinstock George M Metzker Michael L Muzny Donna M Sodergren Erica J Scherer Steven Scott Graham Steffen David Worley Kim C Burch Paula E Okwuonu Geoffrey Hines Sandra Lewis Lora DeRamo Christine Delgado Oliver Dugan-Rocha Shannon Miner George Morgan Margaret Hawes Alicia Gill Rachel Celera Holt Robert A Adams Mark D Amanatides Peter G Baden-Tillson Holly Barnstead Mary Chin Soo Evans Cheryl A Ferriera Steve Fosler Carl Glodek Anna Gu Zhiping Jennings Don Kraft Cheryl L Nguyen Trixie Pfannkoch Cynthia M Sitter Cynthia Sutton Granger G Venter J Craig Woodage Trevor |
| |
Affiliation: | Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, MS BCM226, One Baylor Plaza, Houston, Texas 77030, USA . |
| |
Abstract: | The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|