Medical genetics: a marker for Stevens-Johnson syndrome |
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Authors: | Chung Wen-Hung Hung Shuen-Iu Hong Hong-Shang Hsih Mo-Song Yang Li-Cheng Ho Hsin-Chun Wu Jer-Yuarn Chen Yuan-Tsong |
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Affiliation: | Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan. |
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Abstract: | Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome. |
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