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| 4-氨基苯甲酸的合成工艺研究 | |
| 引用本文： | 周石洋,陈玲,袁月华. 4-氨基苯甲酸的合成工艺研究[J]. 天津师范大学学报(自然科学版), 2013, 33(1): 93-96 |
| 作者姓名： | 周石洋 陈玲 袁月华 |
| 作者单位： | 1. 重庆牧哥食品有限公司,重庆,401520 2. 西南大学育才学院,重庆401524; 3. 湖南机电职业技术学院,长沙,410151 |
| 基金项目： | 四川省科技计划资助项目，西南民族大学创新科技基金资助项目 |
| 摘 要： | 以苯胺为原料，经酰基化、碘仿两步反应合成得到了目标产物4-氨基苯甲酸，并采用IR、^1H NMR和^13C NMR对产物结构进行了表征；探讨酰基化反应时催化剂AlCl3的用量、反应温度及反应时间对中间体4-氨基苯乙酮产率的影响，以及碘仿反应中反应温度、反应时间和滴加4-氨基苯乙酮速率对产物产率的影响．在此合成条件下，4-氨基苯甲酸的产率为94．0％，纯度99．7％． |
| 关 键 词： | 4-氨基苯甲酸 苯胺 酰基化 碘仿 |
Synthesis of 4-amino benzoic acid |
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| ZHOU Shiyang , CHEN Ling , YUAN Yuehua. Synthesis of 4-amino benzoic acid[J]. Journal of Tianjin Normal University(Natural Science Edition), 2013, 33(1): 93-96 | |
| Authors: | ZHOU Shiyang CHEN Ling YUAN Yuehua |
| Affiliation: | 1.Chongqing MuGe Food Co.,Ltd.,Chongqing 401520,China;2.YuCai College,Southwest University, Chongqing 401524,China;3.Hunan Mechanical and Electrical Polytechnic,Changsha 410151,China) |
| Abstract: | With aniline as raw material, through acylation and iodoform reactions, the target compound 4-amino benzoic acid was synthesized and characterized by IR, ^1H NMR and ^13C NMR. In the acylation reaction, the influences of dosage of catalyst AlCl3, reaction temperature and reaction time on the yield of intermediate 4-amino acetophenone were investigated. In the iodoform reaction, the influences of reaction temperature, reaction time and dropping speed of 4-amino acetophenone on the yield of 4-amino benzoic acid were investigated. Under the optimal conditions, the yield of 4-amino benzoic acid was 94.0% with purity of 99.7%. |
| Keywords: | 4-amino benzoic acid aniline acylation iodoform |
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