| N,N′-双{双[4-(二甲氨基)苯基]甲基}尿素合成的反应机理 |
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| 引用本文： | 辛忠,祁国珍.N,N′-双{双[4-(二甲氨基)苯基]甲基}尿素合成的反应机理[J].华东理工大学学报(自然科学版),1993(4). |
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| 作者姓名： | 辛忠 祁国珍 |
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| 作者单位： | 华东化工学院精细化工系
(辛忠)，华东化工学院精细化工系(祁国珍) |
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| 摘 要： | 由对二甲氨基苯甲醛(A)和N,N′-二甲基苯胺(B)在盐酸存在下与尿素反应,合成题示化合物。研究了它的反应机理。结果表明,在强酸存在下,该反应是分两步进行的。首先是A和B缩合形成米氏醇(4,4′-二甲氨基二苯甲醇)中间物,然后再与尿素作用得到尿素衍生物。同时证明,该类取代苯甲醛与取代芳胺,在强酸介质中与尿素作用合成相应的尿素衍生物,都是按上述两步机理进行的。
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| 关 键 词： | 反应机理 压、热敏染料 米氏醇 对二甲氨基苯甲醛 N N’-双{双[4-(二甲氨基)苯基]甲基}尿素 尿素衍生物 |
Reaction Mechanism for Synthesizing N, N'-Bis{his[(p-dimethylamino)phenyl]methyl} urea |
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| Xin Zhong and Qi Guozhen.Reaction Mechanism for Synthesizing N, N''''-Bis{his[(p-dimethylamino)phenyl]methyl} urea[J].Journal of East China University of Science and Technology,1993(4). |
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| Authors: | Xin Zhong and Qi Guozhen |
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| Institution: | Department of Fine Chemicals Technology |
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| Abstract: | The title compound was synthesized by the condensation of p-dimethylaminobenzaldehyde(A), N,N-dimethylaniline(B) with urea in the present of conc. HCI. The resuits showed clearly that the synthetic machanism appears to be a two-step process, Viz. (1) dimethylaminobenzohydrol as Michler's Hydrol is formed by the aldol condensation between A and B and (2) Elimination of water between Michler's Hydrol as intermediate and urea proceeds to form the urea derivative. The reaction mechanisms of other urea derivatives formed by the condensation of substitute arylaldehyde, arylaniline with urea in strong acidic media are the same as the two-step mechanism mentioned above. |
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| Keywords: | reaction mechanism Michler's Hydrol p-dimethylaminobenzaldehyde N N'bis{bis[(p-dimethylamino)phenyl]methyl}urea urea derivatives |
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