口腔扁平苔藓中Caspase-3和PTEN 蛋白的免疫组织化学观察

目的：探讨Caspase-3和FIEN蛋白在口腔扁平苔藓病变发生发展中的作用及两者间的关系。方法：采用S—P免疫组化方法对28例口腔扁平苔藓及5例正常口腔黏膜中Caspase-3和PTEN蛋白表达进行检测。结果：口腔扁平苔藓病损中Caspase-3的阳性率上皮层和固有层均为100％，与正常口腔黏膜相比，表达有显著统计学意义（P〈0．01）。口腔扁平苔藓病损中PTEN蛋白阳性率为100％，与正常口腔黏膜相比，无统计学差异（P〉0．05）。口腔扁平苔藓中Caspase-3与PTEN蛋白表达呈正相关，（P〈0．05）。结论：Caspase-3和PTEN蛋白均参与口腔扁平苔藓病变的发生及发展过程，且两者之间具有相关性。

Immunohistochemical observation of Caspase- 3 and PTEN in oral lichen planus

Aim: To study the roles of Caspase-3 and PTEN and their possible relationship in pathogenesis and development of oral lichen planus(OLP).Methods: 28 OLP and 5 normal oral mucosa samples were analyzed for the expression of Caspase-3 and PTEN,using the S-P immunohistochemical technique.Results: Caspase-3 was found in both the epithelial layer and the lamina propria of all OLP cases,and was significantly higher levels than that in normal oral mucosal tissues(P<0.01).The positive rates of PTEN determined in both normal oral mucosa and OLP cases were 100%,and showed no significant difference between both groups(P>0.05).The expression of Caspase-3 was positively correlated to PTEN in OLP(P< 0.05).Conclusion: Our findings suggest that both Caspase-3 and PTEN may play a role in the pathogenesis and development of OLP,and there is a relationship between them.