| 川芎嗪对大鼠脑缺血-再灌注脑内NOS变化的作用 |
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| 引用本文： | 朱晓琴,唐省三,李萍. 川芎嗪对大鼠脑缺血-再灌注脑内NOS变化的作用[J]. 江汉大学学报(自然科学版), 2004, 32(2): 9-11 |
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| 作者姓名： | 朱晓琴 唐省三 李萍 |
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| 作者单位： | 咸宁学院,生理学教研室,湖北,咸宁,437100;孝感学院,湖北,孝感,432000;成宁学院,医务室,湖北,成宁,437100 |
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| 摘 要： | 目的 :研究川芎嗪 (TMP)对大鼠脑缺血 -再灌注皮层和海马一氧化氮合酶 (NOS)变化的作用。方法 :阻断大鼠双侧颈总动脉 15min和再灌注 2 4h建立脑缺血 -再灌注损伤模型 ,用NADPH d组化技术检测脑NOS阳性细胞数目的变化和TMP对脑缺血 再灌注过程中NOS阳性细胞数目的影响。结果 :脑缺血 再灌注 2 4h后 ,皮层和海马NOS阳性细胞数目显著增多 ,TMP(2 0mg·kg-1和 4 0mg·kg-1)缺血前 30min腹腔注射 ,可明显抑制其增多 ,与NOS拮抗剂L NAME 10mg·kg-1的作用相似。结论 :TMP能降低脑内NOS的活性 ,对脑缺血可能产生保护作用
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| 关 键 词： | 脑缺血-再灌注 一氧化氮合酶 川芎嗪 |
| 文章编号： | 1009-1777(2004)02-0009-03 |
| 修稿时间： | 2004-02-10 |
Effect of Ligustrazine on the Change of NOS in Cerebral Ischemia-reperfusion Rats |
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| ZHU Xiao-qin ,TANG Xing-san ,LI Ping. Effect of Ligustrazine on the Change of NOS in Cerebral Ischemia-reperfusion Rats[J]. Journal of Jianghan University(Natural Sciences), 2004, 32(2): 9-11 |
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| Authors: | ZHU Xiao-qin TANG Xing-san LI Ping |
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| Affiliation: | ZHU Xiao-qin 1,TANG Xing-san 2,LI Ping 3 |
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| Abstract: | Objective:To study the effect of ligustrazine (TMP) on the change of NOS activity in cortex and hippocampus in a rat ischemia-reperfusion model.Methods: Cerebral ischemia-reperfusion of rats was induced by bilaterally occlusion of common cartid arteries for 15min and reperfusion for 24h. NADPH-diaphorase histochemical staining was used to detect the NOS-positive cells.Results: The numbers of NOS-positive cells in cortex and hippocampus increased significantly in ischemia-reperfusion rats ,which was inhibited by TMP(20 and 40mg/ kg ip,30 min before ischemia). The effect of TMP was similar to that of L-NAME,a inhibitor of NOS.Conclusions:TMP may protect brain from ischemic injury by inhibition of NOS during cerebral ischemia-reperfusion. |
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| Keywords: | ischemia-reperfusion brain NOS histochemistry ligustrazine |
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