Preparation and Photodynamic Anti-tumor Activity of Magnetic Polylactic Acid Nanoparticles Loaded with Photosensitizer |
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| Authors: | YANG Xiao-xia HUANG Hui CHEN Zhi-long HUANG Peng SUN Yun ZHOU Xing-ping |
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| Affiliation: | 1. Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai 201620, China;College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China |
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| Abstract: | A novel magnetic nanocarrier was strategically designed and successfully prepared.Photosensitizer 2,7,12,18-tetramethyl-3,8-di-(1-propoxyethyl)-13,17-bis-(3-hydroxypropyl)porphyrin(PHPP)was encapsulated into polylactic acid(PLA)-coated Fe3O4 nanoparticles.The diameter of nanocarrier is 30-50 nm by transmission electron micrograph(TEM).The encapsulation efficiency of photosensitizer is 27.98% calculated from UV-vis absorption spectra.The nanocarrier shows obvious photocytotoxic activity to Hela299 tumor cell... |
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| Keywords: | photocytotoxic activity photosensitizer polylactic acid(PLA) magnetic nanocarriers tumor |
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