Effect of cyclophosphamide on development of reticulum cell sarcoma in SJL/J mice |
| |
Authors: | C G Crispens Jr |
| |
Institution: | (1) Department of Biology, University of Alabama in Birmingham, University Station, 35294 Birmingham, Albama, USA |
| |
Abstract: | Summary Studies to determine the effect of cyclophosphamide (CY) on the development of reticulum cell sarcoma (RCS) in SJL/J mice
indicated a dependence on the duration of the test period. Age also appeared a factor of importance. Thus, a comparison of
tumor incidences at 52 weeks of age showed maximal inhibition when CY was administered at 40 weeks, minimal inhibition when
the drug was given at 30 weeks, and intermediate inhibition when treatment was initiated at 10 and 20 weeks. Consistent with
these findings, long-term treatment of 40-week-old SJL/J mice with low doses of CY resulted in an increase in the mean survival
time and in a reduction in the incidence of RCS.
This work was supported in part by a University College Faculty Research Grant. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|