Presence of calcium ions as a requisite for the in vitro stimulation of TSH-release by hypothalamic TRF |
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| Authors: | W Vale R Burgus R Guillemin |
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| Institution: | (1) Department of Physiology, Baylor University College of Medicine Houston, 77025, Texas, USA |
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| Abstract: | Résumé L'incubation in vitro de fragments d'hypophyse (rat) dans le liquide de Krebs-Ringer sans calcium (Ca++) inhibe l'action du facteur hypothalamique TRF (TSH-releasing factor) qui normalement stimule la sécrétion de l'hormone thyréotrope (TSH). La ré-introduction de l'ion Ca++ (2.54 mM) rétablit la réponse (sécrétion de TSH) au facteur TRF.
Supported by USPHS research grants Nos. AM 08290.04, HD 02577.01, training grant No. GM 956.04; also No. FR 00254 to Common Research Computer Facility, Texas Medical Center. We are pleased to acknowledge the excellent assistance of Mrs.Nancy Pace in the assays involved here. |
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