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Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone |
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| Authors: | P. S. Bhathal S. L. Ho M. P. Hegarty Roger L. N. Harris |
| Affiliation: | (1) Department of Anatomical Pathology, The Royal Melbourne Hospital, Post Office, 3050 Parkville, Victoria, (Australia);(2) Department of Pathology, University of Melbourne, 3052 Parkville, Victoria, (Australia);(3) Division of Tropical Crops and Pastures, C.S.I.R.O., 4067 St. Lucia, Queensland, (Australia);(4) Division of Plant Industry, C.S.I.R.O., 2601 Canberra City, A.C.T., (Australia) |
| Abstract: | Summary Chronic active hepatitis was selectively induced in mice by the feeding of a diet containing 3-hydroxy-4-pyrone (0.5% by weight) for periods of 6 weeks and longer. This model should be of particular value in elucidating the pathogenesis of drug-induced forms of chronic active hepatitis. Maltol (3-hydroxy-2-methyl-4-pyrone) did not produce any liver lesion.Acknowledgment. This research was supported in part by a grant from the Sir A.E. Rowden White Bequest to the Department of Pathology, University of Melbourne.To whom correspondance and requests for reprints should be addressed. |
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