| 一种手性金鸡纳季铵盐的合成及催化α,β-不饱和酮的Michael加成反应研究 |
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| 引用本文： | 郭雄明,王心良,蒋宗林,陈琳,齐斌.一种手性金鸡纳季铵盐的合成及催化α,β-不饱和酮的Michael加成反应研究[J].西华师范大学学报(哲学社会科学版),2009,30(1):104-107. |
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| 作者姓名： | 郭雄明 王心良 蒋宗林 陈琳 齐斌 |
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| 作者单位： | 西华师范大学化学化工学院,四川南充637009 |
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| 基金项目： | 四川省教育厅自然科学基金重点项目(2004A103);;西华师范大学科研项目启动基金(05B031) |
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| 摘 要： | 间-二溴甲基苯与辛可尼定在EtOH—DMF—CHCl，混合溶剂中回流6～7h，得到溴化α,α′-双辛可尼定-m-二甲苯，产率70％．将其用于催化查尔酮与丙二酸二乙酯的Michael加成反应，获得了最高产率70％，最大e．e％值为89％的对映选择性．
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| 关 键 词： | 辛可尼定 查尔酮 Michael加成反应 合成 |
Research on Synthesis and Catalyzed Activity for Michael Reaction of α,β - unsaturated Ketone to a Cinchona Alkaloid Quaternary Ammonium Salt |
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| GUO Xiong-ming,WANG Xin-liang,JIANG Zong-lin,CHEN Lin,QI Bin.Research on Synthesis and Catalyzed Activity for Michael Reaction of α,β - unsaturated Ketone to a Cinchona Alkaloid Quaternary Ammonium Salt[J].Journal of China West Normal University:Natural Science Edition,2009,30(1):104-107. |
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| Authors: | GUO Xiong-ming WANG Xin-liang JIANG Zong-lin CHEN Lin QI Bin |
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| Institution: | School of Chemistry and Chemical Engineering;China West Normal University;Nanchong 637009;China |
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| Abstract: | The mixture of 1,3 -Bis（bromomethyl）benzene and cinchonidine was refluxed in ethanol, DMF, chlor-oform for 6 - 7 h to give α, α′-biscinchonidinium-m-xylene dibromide in 70% yield, and Catalyze Michael Reac-tion, up to 70% yield and 89 e. e %. |
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| Keywords: | Cinchonidine Cinchonidium Chalcone Michael Reaction synthesis |
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