碳离子束放射治疗肿瘤的临床进展

带电粒子治疗肿瘤通常被认为是肿瘤放射治疗的前沿技术，目前在临床广泛用于肿瘤治疗的主要是质子和碳离子。世界范围内现已建成运行的质子治疗中心较多，但是碳离子束放疗中心较少，截至目前，只有日本、德国、中国、意大利、奥地利等少数几个国家应用于临床，日本自1994年以来一直在用碳离子束治疗癌症，且目前日本国内已有6个碳离子中心在运营收治病人，尚有数个中心正在建设中。到2018年底为止，世界范围内超过24905名患者接受了碳离子治疗，190036名患者接受了质子治疗。总结这20几年来碳离子在临床应用的经验可以使我们进一步了解肿瘤放射治疗前沿进展，并帮助指导关于新的重离子治疗中心的设计和建设的战略决策。

Clinical Progress of Carbon Ion Radiotherapy

Charged particle therapy is generally regarded as cutting-edge technology in oncology. Many proton therapy centres are active in the USA, Europe, and Asia, but there is only a few carbon-ion radiotherapy centres. Japan has been treating cancer with high-energy carbon-ions since 1994,there are currently six carbon-ion centers are working on, and several more are under construction. So far, more than 24, 000 patients have had carbon-ion radiotherapy treatment worldwidely. More than 20 years of clinical experience can help guide strategic decisions on the design and construction of new heavy ion therapy centres and give patience''s better options.