Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis |
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Authors: | Email author" target="_blank">Rui-Cheng?JiEmail author |
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Institution: | (1) Department of Human Anatomy, Oita University Faculty of Medicine, Oita 879-5593, Japan |
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Abstract: | The lymphatic system provides important functions for tissue fluid homeostasis and immune response. Lymphangiogenesis, the
formation of new lymphatics, comprises a series of complex cellular events in vitro or in vivo, e.g., proliferation, differentiation,
and sprouting. Recent evidence has implied that macrophages act as a direct structural contributor to lymphatic endothelial
walls or secret VEGF-C/-D and VEGF-A to initiate lymphangiogenesis in inflamed or tumor tissues. Bone marrow-derived macrophages
are versatile cells that express different functional programs in response to exposure to microenvironmental signals, and
can be identified by specific expression of a number of proteins, F4/80, CD11b, and CD68. Several causative factors, e.g.,
NF-κB, IL-1β, TNF-α, SDF-1, M-CSF, especially TonEBP/VEGF-C signaling, may be actively involved in macrophage-induced lymphangiogenesis.
Alteration of macrophage phenotype and function has a profound effect on the development and progression of inflammation and
malignancy, and macrophage depletion for controlling lymphangiogenesis may provide a novel approach for prevention and treatment
of lymphatic-associated diseases. |
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Keywords: | |
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