Antioxidant Activity In Vitro of Three Constituents from Caesalpinia sappan L |
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Authors: | Jun Hu, ú , Xiaoling Yan, ë , Wei Wang, ÿ , Hao Wu,
, Lei Hua, ,Lijun Du, |
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Affiliation: | aLaboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China |
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Abstract: | Antioxidant activities of the 95% ethanol extract from Caesalpinia sappan heartwood (ECS), protosappanin A, protosappanin B, and brazilein were studied in vitro. The inhibition of the formation of malondialdehyde (MDA) and the scavenging of superoxide anions, hydrogen peroxide, and hydroxyl radicals were assayed. The experimental results show that all four substances had antioxidant activity in vitro but their capabilities differed for the different indicators. ECS, protosappanin A, and protosappanin B show more inhibition of MDA and scavenging of hydrogen peroxide, while brazilein shows more scavenging of hydroxyl radicals. All the samples show little scavenging of superoxide anions. |
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Keywords: | antioxidant Caesalpinia sappan L protosappanin A protosappanin B brazilein |
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