Effect of papain on experimental amyloidosis |
| |
Authors: | J Kopolovicz M Fields A Laufer |
| |
Institution: | (1) Department of Pathology, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, (Israel);(2) Present address: Ministry of Health, Jerusalem, (Israel) |
| |
Abstract: | Summary Experimental amyloidosis was induced in mice by repeated injections of complete Freund's adjuvant (CFA) reinforced with a bacterial vaccine. Papain was administered i.p. at various time intervals during the treatment with CFA. Amyloidosis was found only in the spleen and the liver. No statistically significant differences were found between the papain-treated and the control groups. It is assumed that, although papain released the polysaccharide moiety from the polysaccharide protein complex, the released polysaccharides were most probably bound by electrostatic forces to the amyloid fibres, and did not interfere with amyloidogenesis. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|