复方中药一贯煎的抗炎药效评价

为观察复方中药一贯煎的抗炎作用效果,一贯煎全方经过煎煮浓缩后,采用测定角叉菜胶致炎后大鼠左后足的肿胀率,及二甲苯致小鼠耳廓肿胀后耳廓肿胀度,及耳廓肿胀抑制率的方法对一贯煎的抗炎作用效果进行评价。一贯煎浓缩液对大鼠足肿胀有一定的抑制作用,差异明显(p0.05),起效时间相对于阳性对照药物稍长持续时间较长(p0.05);一贯煎浓缩液对二甲苯致小鼠耳廓肿胀也有一定的抑制作用,差异明显(p0.05)。研究结果表明通过行为学观察,可以得知一贯煎具有与阿司匹林相同的抗炎作用。

The Pharmacodynamic evalution on anti-inflammation for Compound traditional Chinese medicine of Yi Guanjian decoction

Objective: Aimed at observing the anti-inflammatory effect of Yi Guanjian decoction. Method: After decocting and concenttrating all the Chinese herbal medicinal ingredient of Yi Guanjian, the methods that we had adopted to measure the left hind paw swelling degree of Sprague-Dawley induced by carrageenin and auricular swelling degree and resistant rate caused by dimthylphenanthrene were taken as indexes to analyze the anti-infammatory function of Yi Guanjian decoction. Results: The concentrated solution of Yi Guanjian has certain inhibitory effect on the foot swelling of rats, and has an obvious difference that compared to the model group (p<0.05), its work time slightly longer than the positive group. Conclusion: The research indicated that Yi Guanjian decoction has some certain anti-inflammatory effect and has equal effect with aspirin.