| 复方中药一贯煎的抗炎药效评价 |
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| 引用本文： | 水素芳,沈淑洁,杨建云,肖炳坤,黄荣清.复方中药一贯煎的抗炎药效评价[J].科学技术与工程,2016,16(25). |
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| 作者姓名： | 水素芳 沈淑洁 杨建云 肖炳坤 黄荣清 |
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| 作者单位： | 安徽医科大学,军事医学科学院放射与辐射医学研究所,军事医学科学院放射与辐射医学研究所,军事医学科学院放射与辐射医学研究所,军事医学科学院放射与辐射医学研究所 |
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| 基金项目： | 二五国家科技重大专项(2012ZX09301003-001-010)、国家自然科学基金(21375147)、北京自然科学基金(7142125)、国家科技科技重大新药创制专项课题(2013ZX09102-016)资助；第一 |
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| 摘 要： | 为观察复方中药一贯煎的抗炎作用效果,一贯煎全方经过煎煮浓缩后,采用测定角叉菜胶致炎后大鼠左后足的肿胀率,及二甲苯致小鼠耳廓肿胀后耳廓肿胀度,及耳廓肿胀抑制率的方法对一贯煎的抗炎作用效果进行评价。一贯煎浓缩液对大鼠足肿胀有一定的抑制作用,差异明显(p0.05),起效时间相对于阳性对照药物稍长持续时间较长(p0.05);一贯煎浓缩液对二甲苯致小鼠耳廓肿胀也有一定的抑制作用,差异明显(p0.05)。研究结果表明通过行为学观察,可以得知一贯煎具有与阿司匹林相同的抗炎作用。
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| 关 键 词： | 一贯煎 抗炎 行为学 |
| 收稿时间： | 2016/4/25 0:00:00 |
| 修稿时间： | 2016/4/26 0:00:00 |
The Pharmacodynamic evalution on anti-inflammation for Compound traditional Chinese medicine of Yi Guanjian decoction |
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| SHUI Su-fang,SHEN Shu-jie,YANG Jian-yun,XIAO Bing-kun and.The Pharmacodynamic evalution on anti-inflammation for Compound traditional Chinese medicine of Yi Guanjian decoction[J].Science Technology and Engineering,2016,16(25). |
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| Authors: | SHUI Su-fang SHEN Shu-jie YANG Jian-yun XIAO Bing-kun and |
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| Institution: | Institute of Radiation Medicine,Academy of Military Medical Science,Institute of Radiation Medicine,Academy of Military Medical Science,Institute of Radiation Medicine,Academy of Military Medical Science, |
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| Abstract: | Objective: Aimed at observing the anti-inflammatory effect of Yi Guanjian decoction. Method: After decocting and concenttrating all the Chinese herbal medicinal ingredient of Yi Guanjian, the methods that we had adopted to measure the left hind paw swelling degree of Sprague-Dawley induced by carrageenin and auricular swelling degree and resistant rate caused by dimthylphenanthrene were taken as indexes to analyze the anti-infammatory function of Yi Guanjian decoction. Results: The concentrated solution of Yi Guanjian has certain inhibitory effect on the foot swelling of rats, and has an obvious difference that compared to the model group (p<0.05), its work time slightly longer than the positive group. Conclusion: The research indicated that Yi Guanjian decoction has some certain anti-inflammatory effect and has equal effect with aspirin. |
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| Keywords: | Yi Guanjian anti-inflammation behaviors |
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