| 4,4-二甲基-2-对甲苯基-4,5-二氢-2H-吡咯并[2,3,4-kl]吖啶-1-酮的简便合成和结构表征 |
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| 引用本文： | 王倩,吴楠,贺玲,姜波.4,4-二甲基-2-对甲苯基-4,5-二氢-2H-吡咯并[2,3,4-kl]吖啶-1-酮的简便合成和结构表征[J].徐州师范大学学报(自然科学版),2013(3):52-56. |
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| 作者姓名： | 王倩 吴楠 贺玲 姜波 |
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| 作者单位： | [1]徐州医学院基础学院生化与化学实验室,江苏徐州221004 [2]徐州空军学院物资油料系化学教研室,江苏徐州221000 [3]江苏师范大学化学化工学院,江苏徐州221116 |
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| 基金项目： | 国家青年基金资助项目（21102124）,江苏省高校自然科学基金资助项目（10KJB150018）,江苏省有机合成重点实验室开放课题（2010jsk15） |
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| 摘 要： | 在醋酸溶剂中,以靛红和5,5-二甲基-3-对-甲苯基氨基-环己-2-烯酮为原料,110℃微波辐射下较高产率地合成吡咯并2,3,4-kl]吖啶-1-酮类化合物.其结构通过单晶X射线衍射法确定,晶体属三斜晶系,空间群P1,Mr=340.41,晶胞参数a=0.978 43(14)nm,b=1.002 76(15)nm,c=1.029 60(16)nm,V=0.881 7(2)nm3,Z=2,晶胞密度Dc=1.282Mg·m-3,吸收系数μ=0.079mm-1,单胞中电子的数目F(000)=360.晶体结构用直接法解出,经全矩阵最小二乘法对原子参数进行修正,最终的偏离因子R=0.048 2,Rw=0.101 6.在晶体结构中新形成的吡咯与吡啶杂环近似于平面结构.
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| 关 键 词： | 吡咯并[2 3 4-kl]吖啶-1-酮 靛红 合成 晶体结构 |
Synthesis and crystal structure of 4,4-dimethyl-2-p-tolyl-4,5-dihydro -2H-pyrrolo[-2,3,4-kl] acridin-l-one |
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| Wang Qian,Wu Nanz,He Ling,Jiang Bo.Synthesis and crystal structure of 4,4-dimethyl-2-p-tolyl-4,5-dihydro -2H-pyrrolo[-2,3,4-kl] acridin-l-one[J].Journal of Xuzhou Normal University(Natural Science Edition),2013(3):52-56. |
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| Authors: | Wang Qian Wu Nanz He Ling Jiang Bo |
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| Institution: | 1. Experimental Center for Biochemistry Chemistry Teaching,School of Basic Seiences,Xuzhou Medical College Xuzhou 221004 ,Jiangsu, China 2. Department of Aviation Oil . Material,Xuzhou Airforee College,Xuzhou 221000,Jiangsu,China 3. School of Chemistry Chemical Engineering,Jiangsu Normal University,Xuzhou 221116 ,Jiangsu,China) |
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| Abstract: | The title compound （C23 H20 N2 O） was synthesized by the reaction of isatin and 5,5-dimethyl-3-p-tolylami- no-cyclohex-2-enone in HOAc at 110 ~C under microwave irradiation. The structure of title product was determined by single crystal X-ray diffraction. The crystal is triclinic, space group P 1, with Mr = 340.41, a = 0. 978 43 （14） nm, b=1.002 76（15） nm, c=1.029 60（16） nm, V=0.881 7（2） nma,Z=2, Dc=1.282 Mg. m-3, μ=0.079 mm-1 , F（000）=360. The structure was solved by direct methods and refined by full-matrix least squares method to the final R=0. 048 2,Rw=0. 101 6. X-ray analysis reveals that the formation of new pyridine ring and pyrrole ring in the crystal structure are plane structure. |
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| Keywords: | pyrrolo[2 3 4-kl]acridin-l-one isatin synthesis crystal structure |
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