Reduction of serum X-prolyl dipeptidyl-aminopeptidase activity in tumour-bearing mice and reversal of reduced enzyme activity by lentinan,an anti-tumour polysaccharide |
| |
| Authors: | T Kato T Nagatsu T Shiio S Sakakibara |
| |
| Institution: | (1) Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, 227 Yokohama, Japan;(2) Research Institute for Life Sciences, Central Research Laboratories, Ajinomoto Co., INC., 244 Yokohama, Japan;(3) Peptide Institute, Protein Research Foundation, Minoh, 562 Osaka, Japan |
| |
| Abstract: | Summary Serum X-prolyl dipeptidyl-aminopeptidase activity which had been shown to be depressed in cancer patients was clearly reduced in mice with Ehrlich carcinoma and Sarcoma 180, and slightly reduced in mice with methylcholanthrene-induced sarcomas. The reduced enzyme activity was completely reversed during tumour regression of sarcoma 180 by administration of lentinan, which causes regression of sarcoma 180. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
