Functions of VEGF in female reproductive system |
| |
Authors: | Qian?Dong Email author" target="_blank">Zhu?ChengEmail author |
| |
Institution: | QIAN Dong & ZHU Cheng State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China |
| |
Abstract: | As a homodimeric glycoprotein, vascular en- dothelial growth factor (VEGF) is a highly specific mitogen of vascular endothelial cells. It can induce proliferation and migration, and inhibit apoptosis of endothelial cell. VEGF is involved in many processes in the female reproductive sys-tem, such as ovulation, periodical changes of endometrium, embryo implantation and development. VEGF plays impor-tant roles in some reproductive diseases, including pree-clampsia and fetal hypoevolutism in uterus. Based on our studies on angiogenesis and its relevant factors in the female reproductive system these years, the functions of VEGF in female reproductive system are reviewed, and the research prospect and application of VEGF are also discussed. |
| |
Keywords: | VEGF angiogenesis female reproductive system VEGF receptors vascular permeability |
本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录! |
| 点击此处可从《中国科学通报(英文版)》浏览原始摘要信息 |
| 点击此处可从《中国科学通报(英文版)》下载免费的PDF全文 |