Type-2 copper-containing enzymes |
| |
Authors: | I S MacPherson M E P Murphy |
| |
Institution: | (1) Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada;(2) Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada |
| |
Abstract: | Type-2 Cu sites are found in all the major branches of life and are often involved in the catalysis of oxygen species. Four
type-2 Cu protein families are selected as model systems for review: amine oxidases, Cu monooxygenases, nitrite reductase/multicopper
oxidase, and CuZn superoxide dismutase. For each model protein, the availability of multiple crystal structures and detailed
enzymological studies provides a detailed molecular view of the type-2 Cu site and delineation of the mechanistic role of
the Cu in biological function. Comparison of these model proteins leads to the identification of common properties of the
Cu sites and insight into the evolution of the trinuclear active site found in multicopper oxidases.
Received 6 July 2007; accepted 18 July 2007 |
| |
Keywords: | Nitrite reductase amine oxidase superoxide dismutase dopamine monooxygenase peptidyl amidating enzyme |
本文献已被 PubMed SpringerLink 等数据库收录! |
|