Benzyn-Zwischenprodukte in der nukleophilen aromatischen Substitution |
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| Authors: | Erwin F. Jenny Marjorie C. Caserio John D. Roberts |
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| Affiliation: | (1) Pharm.-wiss. Abteilung der CIBA A.-G., Basel;(2) California Institute of Technology, Pasadena 4, California, U.S.A. |
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| Abstract: | Summary Many substitution reactions of aromatic halides, such as amination with metallic amides in ammonia or amine solutions, high-temperature alkaline hydrolyses and arylation with phenyllithium, lead to the formation of rearrangement products as the result of a common reaction path involving unstable  benzyne intermediates. The chemical evidence in favor of this reaction mechanism is discussed as are correlations of observed product compositions and applications to practical synthetic procedures.
Contribution No. 2390. |
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